By Frederick W. Alt

ISBN-10: 0123813026

ISBN-13: 9780123813022

Advances in Immunology, a fashioned and hugely revered book, provides present advancements in addition to entire stories in immunology. Articles deal with the big variety of subject matters that contain immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored by means of the key scientists within the box, each one quantity presents updated info and instructions for destiny * Contributions from major gurus and specialists * Informs and updates on all of the most modern advancements within the box

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1997). 3) configuration. 3)-branched galactose could represent a physiological substrate for a-Gal-A. Consequently, enzyme deficiency in a-Gal-A activity could lead to iGb3 accumulation. , 2004b). In contrast to Hexb / mice, this deficit was only partial and specific for iNKT cells located in The Immunological Functions of Saposins 45 peripheral organs. Since Fabry and Sandhoff diseases have different etiologies and display diverse patterns of GSL storage, a generalized defect of iNKT cell selection has been proposed in LSD mice.

1988). These special properties might explain as to why SAP-B stimulates the degradation of a broader spectrum of sphingolipids compared to other SAPs. , 2006). , 1989). , 2003). The concave inner surface of each monomer is lined with hydrophobic residues that create a large lipidbinding cavity when two monomers are associated. In its open conformation, the SAP-B dimer can directly interact with lipid membranes, promote the reorganization of lipid alkyl chains, and extract lipid substrates upon transition to the closed conformation.

4. CD1d-restricted natural killer T cells In contrast to humans, mice lack genes encoding group 1 CD1 molecules. Therefore, their repertoire of lipid-specific T cells is solely represented by lymphocytes restricted to CD1d molecules, namely NKT cells. , 1993). , 2000). , 1997). By definition, NKT cells that respond to a-GalCer are referred to as invariant NKT (iNKT) cells. , 2007). By contrast, NKT cells that fail to respond to a-GalCer stimulation are referred to as noninvariant NKT cells, or type II NKT cells.

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Advances in Immunology, Vol. 105 by Frederick W. Alt

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