By Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler

ISBN-10: 1849731268

ISBN-13: 9781849731263

Money owed in Drug Discovery describes fresh case reports in medicinal chemistry with a specific emphasis on how the inevitable difficulties that come up in the course of any undertaking could be surmounted or triumph over. The Editors conceal a variety of healing parts and medicinal chemistry suggestions, together with lead optimization ranging from excessive throughput screening "hits" in addition to rational, structure-based layout. The chapters contain "follow-ons" and "next new release" compounds that objective to enhance upon first new release brokers. This quantity surveys the diversity of demanding situations quite often confronted by way of medicinal chemistry researchers, together with the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, together with facts of thought within the hospital for novel organic goals. The case experiences comprise medicinal chemistry tales on lately authorized and advertised medicinal drugs, but in addition chronicle "near-misses", i.e., exemplary compounds which could have proceeded good into the medical institution yet for varied purposes didn't bring about a winning registration. because the overwhelming majority of tasks fail sooner than registration, a lot might be discovered from such narratives. via sharing quite a lot of drug discovery stories and knowledge around the group of medicinal chemists in either and academia, we think that those money owed will offer insights into the paintings of medicinal chemistry because it is presently practiced and should support to serve the desires of energetic medicinal chemists.

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Seethala, L. Cheng, P. Sleph, W. Sun, A. Tieman, J. R. Wetterau, A. Doweyko, G. Chandrasena, S. Y. Chang, W. G. Humphreys, V. G. Sasseville, S. A. Biller, D. E. Ryono, F. Selan, N. Hariharan and P. T. W. Cheng, J. Med. , 2005, 48, 2248. The Discovery of the Dipeptidyl Peptidase-4 (DPP4) Inhibitor Onglyzat 21 5. W. Meng, B. A. Ellsworth, A. A. Nirschl, P. J. McCann, M. Patel, R. N. Girotra, G. Wu, P. M. Sher, E. P. Morrison, S. A. Biller, R. Zahler, P. P. Deshpande, A. Pullockaran, D. L. Hagan, N.

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Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery Series, Volume 4) by Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler

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